Mei-Ling Ting Lee


Books

  1. LEE M-LT. Analysis of Microarray Gene Expression Data, (2004), Springer (formerly Kluwer Academic Publishers)

  2. Mesbah M, Cole BF, LEE M-LT, editors, Statistical Methods for Quality of Life Studies Design, Measurements and Analysis, (2002). Springer (formerly Kluwer Academic Publishers)

  3. Jewell NP, Kimber AC, LEE M-LT, Whitmore GA , editors, Lifetime Data: Models in Reliability and Survival Analysis, (1996). Springer (formerly Kluwer Academic Publishers)

Peer reviewed original articles in the following topic areas

(Last updated on 9/22/2010)
  1. Analysis of Genomic and Proteomic Data
  2. Statistical Models and Applied Probability
  3. Applications in Epidemiology, Microbiology & Environmental Studies

Articles in Analysis of Genomic and Proteomic Data

Lee M-LT. Molecular gene-signatures and cancer clinical trials, In: Designs for Clinical Trials: Perspectives on Current Issues. David Harrington, Editor, 139-155. (2011).

Beyer SJ, Zhang X, Jimenez RE, Lee M-LT, Richardson AL, Huang K, Jhiang SM. Microarray analysis of genes associated with cell surface NIS protein levels in breast cancer, BMC Research Notes, 2011, Vol. 4: 397, doi: 10.1186/1756-0500-4-397

Hunter MP, Ismail N, Zhang X, Aguda BD, Lee EJ, Yu L, Xiao T, Schafer J, Lee M-LT, Schmittgen TD, Nana-Sinkam SP, Jarjoura D, Marsh C. Detection of microRNA Expression in Human Peripheral Blood Microvesicles, PLoS ONE, 2008, Vol. 3: 11, e3694

Zhang Y, Bertolino A, Fazio L, Blasi G, Rampino A, Romano R, Lee M-LT, Xiao T, Papp A, Wang D, and Sadée W. Novel polymorphisms in the human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory, Proceedings of the National Academy of Sciences, USA, 2007, 104: 20552-20557.

Qiu W, Lee M-LT. SPCalc: A web-based calculator for sample size and power calculations in micro-array studies, Bioinformation, 2006, 1: 251-252.

Qin S, Qiu W, Ehrlich JR, Ferdinand AS, Richie JP, O扡eary MP, Lee M-LT, Liu BC-S. Development of a reverse capture autoantibody microarray for studies of antigen-autoantibody profiling. Proteomics, 2006, 6: 3199-3209 .

Lee M-LT, Whitmore GA, Bjorkbacka H, Freeman M. Nonparametric Methods for Microarray Data Based on Exchangeability and Borrowed Power. Journal of Biopharmaceutical Statistics, 2005, 15: 783-797 .

Tsai PW, LEE M-LT. Split-plot microarray experiments: issues of design, power and sample size. Applied Bioinformatics, 2005, 4: 187-194.

LEE M-LT, Gray RJ, Bjorkbacka H, Freeman MW. Generalized Rank Tests for Replicated Microarray Data. Statistical Applications in Genetics and Molecular Biology, 2005, Vol. 4: No. 1, Article 3.

Lee M-LT, Whitmore GA. Intensity-dependent normalization in microarray analysis: a note of concern. Bernoulli, 2004, 10: 943-949.

Lee M-LT, Whitmore GA, Yukhananov RY. Analysis of unbalanced microarray data, Journal of Data Science, 2003; 1: 103-121.

Lee M-LT, Whitmore GA. Power and sample size for microarray studies, Statistics in Medicine, 2002; 21: 3543-3570.

Lee M-LT, Bulyk ML, Whitmore GA, Church GM. A statistical model for investigating binding probability of DNA nucleotide sequences using microarrays, Biometrics, 2002; 58: 981-988.

Lee M-LT, Lu W, Whitmore GA, Beier D. Models for microarray gene expression data, Journal of Biopharmaceutical Statistics, 2002; 12: 1-19.

Lee M-LT, Kuo FC, Whitmore GA, Sklar J. Importance of replication in microarray gene expression studies: statistical methods and evidence from repetitive cDNA hybridization. Proceedings of the National Academy of Sciences, 2000; 97: 9834-9839.

Articles in Statistical Models and Applied Probability


Statistical Models

Jialiang Li, Lee M-LT. Analysis of Failure Time Using Threshold Regression with Semi-parametric Varying Coefficients. Statistica Neerlandica (In Press)

Lee M-LT, Whitmore GA, Rosner B. Threshold Regression for Survival Data with Time-varying Covariates. Statistics in Medicine, 2010, 29, 7-8: 896 - 905.

Lee M-LT, Whitmore GA. Proportional hazards and threshold regression: their theoretical and practical connections. Lifetime Data Analysis, 2010, 16, 2: 196-214.

Pennell M, Whitmore GA, Lee M-LT. Bayesian random effects threshold regression with application to survival data with nonproportional hazards. Biostatistics, 2010, 11, 1: 111-126.

Yu Z, Tu W, Lee M-LT. A Semiparametric Threshold Regression Analysis of Sexually Transmitted Infections in Adolescent Women. Statistics in Medicine, 2009, 28:3029-3042.

Lee M-LT, Whitmore GA, Chang M. A Threshold Regression Mixture Model for Assessing Treatment Efficacy in a Multiple Myeloma Clinical Trial. Journal of Biopharmaceutical Statistics, 2008, 18: 1136-1149.

Tong X, He X, Sun J, and Lee M-LT. Joint analysis of current status and marker data: an extension of a bivariate threshold model. The International Journal of Biostatistics, 2008, Vol. 4: Iss. 1, Article 21.

Lee M-LT. Lifetime models and risk assessment. Encyclopedia of Quantitative Risk Assessments, Brian Everitt and Ed. Melnick, editors. Wiley (In Press).

Lee M-LT, Whitmore GA. Threshold regression for survival analysis: modeling event times by a stochastic process reaching a boundary. Statistical Sciences, 2006, 21: 501-513.

Rosner B, Glynn RJ, Lee M-LT. Extension of the Rank Sum Test for Clustered Data: Two-Group Comparisons with Group Membership Defined at the Subunit Level. Biometrics, 2006, 62: 1251-1259.

Rosner B, Glynn RJ, Lee M-LT. The Wilcoxon Signed Rank Test for Paired Comparisons of Clustered Data. Biometrics, 2006, 62: 185-192.

LEE M-LT, Dehling HG. Generalized two-sample U-statistics for clustered data. Statistica Neerlandica, 2005, 59: 313-323.

Shubina M., Lee M-LT. On maximum attainable correlation for Sarmanov family of bivariate distributions with equal marginal distributions, Communications in Statistics: Theory and Methods, 2004, 33: 1031-1052.

Rosner B, Glynn RJ, Lee M-LT, Incorporation of clustering effects for the Wilcoxon rank sum test: a large sample approach. Biometrics, 2003; 59: 1089-1098.

LEE M-LT, Whitmore GA. First Hitting Time Models for Lifetime Data, Handbook of Statistics, Volume 23: Advances in Survival Analysis, edited by N. Balakrishnan and C.R. Rao. Elsevier, North Holland. 2003; 537-543.

Fang HB, Sun J, Lee M-LT, Nonparametric survival comparisons for interval censored continuous data. Statistica Sinica, 2002; 12: 1073-1083.

Lee M-LT, Rosner BA. The average area under correlated ROC curves: a nonparametric approach based on generalized two-sample Wilcoxon statistics. Journal of Royal Statistical Society, series C, Applied Statistics, 2001; 50: 337-344.

Lee M-LT, Schoenfeld D, Wang X, Penfornis A, Faustman D. Bayesian analysis of case control polygenic etiology studies with missing data. Biostatistics; 2001, 2(3): 309-322.

Lee M-LT, DeGruttola V, Schoenfeld D. A model for markers and latent health status. Journal of Royal Statistical Society, Series B, 2000; 62: 747-762.

Lee M-LT, Whitmore GA. Statistical inference for serial dilution assay data. Biometrics, 1999; 55: 1215-1220.

Hougaard P, Lee M-LT, Whitmore GA. Analysis of overdispersed count data by mixtures of Poisson variables and Poisson processes. Biometrics, 1997; 53: 1225-1238.

Williamson JM, Lee M-LT. A GEE regression model for the association between an ordinal and a nominal variable. Communications in Statistics: Theory and Methods, 1996; 25:1887-1901.

Lee M-LT. Properties and applications of Sarmonov's family of bivariate distributions. Communications in Statistics: Theory and Methods, 1996; 25:1207-1222.

Cole BF, Lee M-LT, Whitmore GA, Zaslavsky AM. An empirical Bayes model for Markov dependent binary sequences with randomly missing observations. Journal of American Statistical Association, 1995; 90:1364-72.

Lee M-LT.  A two state Markov model.  Communications in Statistics: Theory and Methods, 1994; 23:615-23.

Benedetti J, Green S, Lee M-LT, Crowley J. Report of the ad hoc committee on design of experiments on double blind refereeing. Statistical Sciences, 1993; 8:318-30.

Lee M-LT, Gross AJ.  Lifetime distributions under unknown environments.  Journal of Statistical Planning and Inferences, 1991; 29:137-43.

Whitmore GA, Lee M-LT. A multivariate survival distribution generated by inverse Gaussian mixture of exponentials. Technometrics, 1991; 33:39-50.

D'Agostino RB, Lee M-LT, Belanger AJ, Cupples LA, Anderson K, Kannel WB.  Relation of pooled logistic regression to time dependent Cox regression analysis: the Framingham Heart Study.  Statistics in Medicine, 1990; 9:1501-15.

Lee M-LT.  A moment test to identify uniformity.  Communications in Statistics: Simulation and Computation, 1989; 18 Part B:253-61.

Lee M-LT.  Some cross product difference statistics and a test for trends in ordered contingency tables.  Statistics and Probability Letters, 1988; 7:41-46.

Block HW, Ting ML.  Some concepts of multivariate dependence.  Communications in Statistics: Theory and Methods, 1981; A10(8):749-62.

Applied Probability

Limnios N, Lee M-LT. Hoeffding's Inequality for Stopped Martingales and Semi-Markov Processes. Communications in Statistics: Theory and Methods, 2005, 34: 713-720.

Lee M-LT, Whitmore GA. Stochastic processes directed by randomized time. Journal of Applied Probability, 1993; 30:302-14.

Lee M-LT, Rachev ST, Samorodnitsky G. Association of stable random variables. Annals of Probability, 1990; 18:1759-64.

Lee M-LT, Gross AJ. Properties of conditionally independent generalized gamma distributions. Probability in the Engineering and Informational Sciences, 1989; 3:289-97.

Lee M-LT. Dependence by reverse regular rule. Annals of Probability, 1985; 13:583-91.

Lee M-LT. Dependence by total positivity. Annals of Probability, 1985; 13:572-82.

Wang HC, Ting ML.  Homogeneous Banach spaces of locally integrable functions.  Nanta Mathematica 1979; 12:62-70.
 

Articles in Epidemiology, Pharmarco Epidemiology, Microbiology & Environmental Studies


Epidemiology

Rosner B, Glynn RJ, Lee M-LT. A Nonparametric Test for Observational Non-Normally Distributed Ophthalmic Data with Eye-Specific Exposures and Outcomes, Ophthalmic Epidemiology, Volume 14, Issue 4 July 2007, pages 243 - 250

Finkelstein JS, Lee M-LT, Sowers MF, Ettinger B, Neer RM,  Kelsey JL, Cauley JA, Huang MH, Greendale GA. Ethnic variation in bone density in premenopausal and early perimenopausal women: effects of anthropometric and lifestyle factors, Journal of Clinical Endocrinology and Metabolism, 2002; 87: 3057-3067.

Finkelstein JS, Sowers MF, Greendale GA, Lee M-LT, Neer RM, Cauley JA, Ettinger B. Ethnic variation in bone turnover in pre- and early perimenopausal women: effects of anthropometric and lifestyle factors. Journal of Clinical Endocrinology and Metabolism, 2002; 87: 3051-3056.

Leder BZ, Smith MR, Fallon M, Lee ML, Finkelstein JS. Effects of gonadal steroid suppression on skeletal sensitivity to parathyroid hormone in men. Journal of Clinical Endocrinology and metabolism, 2001; 86: 511-516.

Zaleznik DF, Rench MA, Hillier S, Krohn MA, Platt R, Lee M-LT, Flores AE, Ferriri P, Baker CJ. Invasive group B streptococcal disease in pregnant women and neonates from diverse population groups. Clinical Infectious Diseases, 2000; 30:276-281.

Lee M-LT, Rosner BA, Weiss ST. Relationship of blood pressure to cardiovascular death: the effects of pulse pressure in the elderly. Annals of Epidemiology, 1999; 9: 101-107.

Platt R, Adelson-Mitty J, Weissman L, Zaleznik D., Lee ML, Baker CJ. Resource utilization associated with initial hospital stays complicated by early-onset group B streptococcal disease. Pediatric Infectious Disease, 1999; 18: 529-533.

Lee M-LT, Rosner BA, Weiss ST, Vokonas PS, Gaziano JM. Predictors of cardiovascular deaths: The Normative Aging Study--1963-1998. Clinical Geriatrics, 1999: 7: 77-85.

Fielding JR, Griffiths DJ, Versi E, Mulkern RV, Lee M-LT, Jolesz FA. MR imaging of pelvic floor continence mechanisms in the supine and sitting positions. American Journal of Roentgenology, 1998; 171: 1607-1610.

Poteat HT, Ho GT, Lee M-LT, Welch WR, Loughlin KR, Sacks DB. The utility of patient age in evaluating prostate cancer, American Journal of Clinical Pathology, 1997; 107: 337-344.

Lee M-LT, Rosner BA, Vokonas PS, Weiss ST. Longitudinal analysis of adult male blood pressure: The Normative Aging Study, 1963-1992. Journal of Epidemiology & Biostatistics, 1996; 1:79-87. 

Hirschorn LR, Trnka Y, Onderdonk A, Lee M-LT, Platt R. Epidemiology of community-acquired clostridium difficile associated diarrhea. Journal of Infectious Diseases, 1994; 169:127-33.

Pharmarco Epidemiology

Choo PW, Rand CS, Inui TS, Lee M-LT, Canning C, Platt R. A cohort study of possible risk factors for over-reporting of antihypertensive adherence, BioMedical Central Cardiovascular Disorders, 2001; 1: 6.

Choo PW, Rand CS, Inui TS, Lee M-LT, Canning C, Platt R. Derivation of adherence metrics from electronic dosing records. Journal of Clinical Epidemiology, 2001; 54: 619-626.

Choo PW, Rand CS, Inui TS, Lee M-LT, Canning C, Platt R. A pharmacodynamic assessment of the impact of antihypertensive non-adherence on blood pressure control. Pharmacoepidemiology and Drug Safety, 2000; 9: 557-563.

Choo PW, Rand CS, Inui TS, Lee M-LT, Cain E, Cordeiro-Breault M, Canning C, Platt R. Validation of patient reports, automated pharmacy records, and pill counts with electronic monitoring or adherence to antihypertensive therapy. Medical Care, 1999; 37: 846-857.

Lee M-LT, Lazarus R. Meta analysis for drug safety data with logistic regressions. Drug Information Journal , 1997; 31: 1189-1193.

Microbiology

Onderdonk AB, Lee M-LT, Liberman E, Delaney ML, Tuomala RE. Quantitative microbiologic models for pre-term delivery, Journal of Clinical Microbiology, 2003, 41: 1073-1079.

Lee M-LT, DuBois A, Ross RA, Onderdonk AB. Nonlinear models for in vitro kill kinetics for antibiotics. Journal of Biopharmaceutical Statistics, 1999; 9: 271-277.

Lee M-LT, Ross RA, Onderdonk AB. Statistical models for vaginal microflora: identifying women at risk for group B streptococcus colonization as a test of concept. Infectious Diseases in Obstetrics and Gynecology. 1997; 5: 336-340.

Lee M-LT, Onderdonk AB. Demonstration of subgroups among normal vaginal microflora data. Microbial Ecology in Health & Disease, 1995; 7:107-12.

Lee M-LT, Ross RA, Onderdonk AB. Cluster analysis of vaginal microflora data, Microecology and Therapy 1995; 25:324-328.

Lee M-LT, Ross RA, Delaney ML, Onderdonk AB. Mathematical modelling of the vaginal microflora. Microecology and Therapy 1995; 23:18-21.

Ross RA, Lee M-LT, Delaney ML, Onderdonk AB. Use of continuous culture growth systems for modelling vaginal microflora behaviour. Microecology and Therapy 1995; 23:16-17.

Ross RA, Lee M-LT, Onderdonk AB. Effect of candida albricans infection and clotrimazole treatment on vaginal microflora in an in vitro model. Obstetrics and Gynecology, 1995; 86:925-30.

Lee M-LT, Ross RA, Delaney ML, Onderdonk AB. Predicting abnormal microbial population levels in the vaginal ecosystem. Microbial Ecology in Health & Diseases, 1994; 7:235-40.

Ross RA, Lee M-LT, Delaney ML, Onderdonk AB. Mixed-effects models for predicting microbial interactions in the vaginal ecosystem. Journal of Clinical Microbiology, 1994; 32:871-75.

Environmental Research

Lee M-LT, Whitmore GA, Laden F, Hart JE, Garshick E. A Case-Control Study Relating Railroad Worker Mortality to Diesel Exhaust Exposure Using a Threshold Regression Model. Journal of Statistical Planning and Inferences, 2009, 139:1633-1642.

Lee M-LT, Whitmore GA, Laden F, Hart JE, Garshick E. Assessing lung cancer risk in railroad workers using a first hitting time regression model. Environmetrics, 2004,15: 501-512.

Tsaih SW, Korrick S, Schwartz J, Lee MLT, Amarasiriwardena C, Aro A, Sparrow D, Hu H. Relation of bone lead and blood lead to renal function among middle-aged and elderly men: the Normative Aging Study. Environmental Health Perspectives. 2004; 112: 1178-82.

Aro A, Amarasiriwardena C, Lee M-LT, Kim R, Hu H. Validation of K x-ray fluorescence bone lead measurements by inductively coupled plasma mass spectrometry in cadaver legs. Medical Physics, 2000; 27: 119-123.

Chuang HY, Schwartz J, Hu H, Lee M-LT. Vibration perception thresholds in workers with long-term lead exposure. Occupational and Environmental Medicine, 2000; 57: 588-594.

Tsaih SWT, Schwartz J, Lee M-LT, Amarasiriwardena C, Aro A, Sparrow D, Hu H. The independent contribution of bone and erythrocyte lead to urinary lead among middle-aged and elderly man: The Normative Aging Study. Environmental Health Perspectives, 1999; 107, 391-396.

Chuang HY, Lee M-LT, Chao KY, Wang JD, Hu H. The relationship of blood lead levels to personal hygiene habits in lead battery workers: Taiwan, 1991-1997. American Journal of Industrial Medicine, 1999; 35: 595-603.