Mei-Ling Ting Lee
LEE M-LT. Analysis of Microarray
Gene Expression Data, (2004), Springer (formerly Kluwer Academic Publishers)
Mesbah M, Cole BF, LEE M-LT, editors,
Methods for Quality of Life Studies Design, Measurements and Analysis,
(2002). Springer (formerly Kluwer Academic Publishers)
Jewell NP, Kimber AC, LEE M-LT, Whitmore GA , editors, Lifetime Data: Models in Reliability and
Analysis, (1996). Springer (formerly Kluwer Academic Publishers)
Peer reviewed original articles in the following topic areas
Articles in Analysis of Genomic and Proteomic Data
Lee M-LT. Molecular gene-signatures and cancer clinical trials, In: Designs for Clinical Trials: Perspectives on Current Issues. David Harrington, Editor, 139-155. (2011).
Beyer SJ, Zhang X, Jimenez RE, Lee M-LT, Richardson AL, Huang K, Jhiang SM. Microarray analysis of genes associated with cell surface NIS protein levels in breast cancer, BMC Research Notes, 2011, Vol. 4: 397, doi: 10.1186/1756-0500-4-397
Hunter MP, Ismail N, Zhang X, Aguda BD, Lee EJ, Yu L, Xiao T, Schafer J, Lee M-LT, Schmittgen TD, Nana-Sinkam SP, Jarjoura D, Marsh C. Detection of microRNA Expression in Human Peripheral Blood Microvesicles, PLoS ONE, 2008, Vol. 3: 11, e3694
Zhang Y, Bertolino A, Fazio L, Blasi G, Rampino A, Romano R, Lee M-LT, Xiao T, Papp A, Wang D, and Sadée W. Novel polymorphisms in the human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory, Proceedings of the National Academy of Sciences, USA, 2007, 104: 20552-20557.
Qiu W, Lee M-LT. SPCalc: A web-based calculator for sample size and power calculations in micro-array studies, Bioinformation, 2006, 1: 251-252.
Qin S, Qiu W, Ehrlich JR, Ferdinand AS, Richie JP, O扡eary MP, Lee M-LT, Liu BC-S. Development of a reverse capture autoantibody microarray for studies of antigen-autoantibody profiling.
Proteomics, 2006, 6: 3199-3209 .
Lee M-LT, Whitmore GA, Bjorkbacka H, Freeman M. Nonparametric Methods for Microarray Data Based on Exchangeability and Borrowed Power.
Journal of Biopharmaceutical Statistics, 2005, 15: 783-797 .
Tsai PW, LEE M-LT. Split-plot microarray experiments: issues of design,
power and sample size. Applied Bioinformatics, 2005, 4: 187-194.
LEE M-LT, Gray RJ, Bjorkbacka H, Freeman MW. Generalized
Rank Tests for Replicated Microarray Data. Statistical Applications
in Genetics and Molecular Biology, 2005, Vol. 4: No. 1, Article 3.
Lee M-LT, Whitmore GA. Intensity-dependent normalization in microarray
analysis: a note of concern. Bernoulli,
2004, 10: 943-949.
Lee M-LT, Whitmore GA, Yukhananov RY. Analysis
of unbalanced microarray data, Journal of Data
Science, 2003; 1: 103-121.
Lee M-LT, Whitmore GA. Power and sample size for microarray studies,
Statistics in Medicine, 2002; 21: 3543-3570.
Lee M-LT, Bulyk ML, Whitmore GA, Church GM. A statistical model for investigating
binding probability of DNA nucleotide sequences using microarrays, Biometrics,
2002; 58: 981-988.
Lee M-LT, Lu W, Whitmore GA, Beier D. Models for microarray gene expression
data, Journal of Biopharmaceutical Statistics, 2002;
Lee M-LT, Kuo FC, Whitmore GA, Sklar J. Importance of replication
in microarray gene expression studies: statistical methods and evidence
from repetitive cDNA hybridization. Proceedings of the National Academy of Sciences,
2000; 97: 9834-9839.
Articles in Statistical Models and Applied Probability
Jialiang Li, Lee M-LT. Analysis of Failure Time Using Threshold Regression with Semi-parametric Varying Coefficients. Statistica Neerlandica (In Press)
Lee M-LT, Whitmore GA, Rosner B. Threshold Regression for Survival Data with Time-varying Covariates. Statistics in Medicine, 2010, 29, 7-8: 896 - 905.
Lee M-LT, Whitmore GA. Proportional hazards and threshold regression: their theoretical and practical connections.
Lifetime Data Analysis, 2010, 16, 2: 196-214.
Pennell M, Whitmore GA, Lee M-LT. Bayesian random effects threshold
regression with application to survival data with nonproportional
hazards. Biostatistics, 2010, 11, 1: 111-126.
Yu Z, Tu W, Lee M-LT. A Semiparametric Threshold Regression Analysis of Sexually Transmitted Infections in Adolescent Women. Statistics in Medicine, 2009, 28:3029-3042.
Lee M-LT, Whitmore GA, Chang M. A Threshold Regression Mixture Model
for Assessing Treatment Efficacy in a Multiple Myeloma Clinical Trial. Journal of Biopharmaceutical Statistics, 2008, 18: 1136-1149.
Tong X, He X, Sun J, and Lee M-LT. Joint analysis of current status
and marker data: an extension of a bivariate threshold model. The International Journal of Biostatistics, 2008, Vol. 4: Iss. 1, Article 21.
Lee M-LT. Lifetime models and risk assessment. Encyclopedia of Quantitative Risk Assessments, Brian Everitt and Ed. Melnick, editors. Wiley (In Press).
Lee M-LT, Whitmore GA. Threshold regression for survival analysis:
modeling event times by a stochastic process reaching a boundary. Statistical Sciences, 2006, 21: 501-513.
Rosner B, Glynn RJ, Lee M-LT. Extension of the Rank Sum Test for
Clustered Data: Two-Group Comparisons with Group Membership Defined at
the Subunit Level. Biometrics, 2006, 62: 1251-1259.
Rosner B, Glynn RJ, Lee M-LT. The Wilcoxon Signed Rank Test for Paired Comparisons of Clustered Data. Biometrics, 2006, 62: 185-192.
LEE M-LT, Dehling HG. Generalized two-sample U-statistics for clustered
data. Statistica Neerlandica, 2005, 59: 313-323.
Shubina M., Lee M-LT. On maximum attainable correlation for Sarmanov family
of bivariate distributions with equal marginal distributions, Communications in Statistics: Theory and Methods,
2004, 33: 1031-1052.
Rosner B, Glynn RJ, Lee M-LT, Incorporation of clustering effects
for the Wilcoxon rank sum test: a large sample approach. Biometrics,
2003; 59: 1089-1098.
LEE M-LT, Whitmore GA. First Hitting Time Models for Lifetime Data,
Handbook of Statistics, Volume 23: Advances in Survival Analysis, edited
by N. Balakrishnan and C.R. Rao. Elsevier, North Holland. 2003; 537-543.
Fang HB, Sun J, Lee M-LT, Nonparametric
survival comparisons for interval censored continuous data. Statistica
Sinica, 2002; 12: 1073-1083.
Lee M-LT, Rosner BA. The average area under correlated ROC curves: a nonparametric
approach based on generalized two-sample Wilcoxon statistics. Journal of Royal Statistical Society, series C, Applied
Statistics, 2001; 50: 337-344.
Lee M-LT, Schoenfeld D, Wang X, Penfornis A, Faustman D. Bayesian analysis
of case control polygenic etiology studies with missing data.
2001, 2(3): 309-322.
Lee M-LT, DeGruttola V, Schoenfeld D. A model for markers and latent
health status. Journal of Royal Statistical Society, Series
B, 2000; 62: 747-762.
Lee M-LT, Whitmore GA. Statistical inference for serial dilution assay
1999; 55: 1215-1220.
Hougaard P, Lee M-LT, Whitmore GA. Analysis of overdispersed count
data by mixtures of Poisson variables and Poisson processes.
1997; 53: 1225-1238.
Williamson JM, Lee M-LT. A GEE regression model for the association
between an ordinal and a nominal variable. Communications in Statistics: Theory and Methods,
Lee M-LT. Properties and applications of Sarmonov's family of bivariate
distributions. Communications in Statistics: Theory and Methods,
Cole BF, Lee M-LT, Whitmore GA, Zaslavsky AM. An empirical Bayes model
for Markov dependent binary sequences with randomly missing observations.
Journal of American Statistical Association, 1995;
Lee M-LT. A two state Markov model. Communications in Statistics: Theory and Methods,
Benedetti J, Green S, Lee M-LT, Crowley J. Report of the ad hoc committee
on design of experiments on double blind refereeing. Statistical Sciences,
Lee M-LT, Gross AJ. Lifetime distributions under unknown environments.
Journal of Statistical Planning and Inferences,
Whitmore GA, Lee M-LT. A multivariate survival distribution generated
by inverse Gaussian mixture of exponentials. Technometrics, 1991; 33:39-50.
D'Agostino RB, Lee M-LT, Belanger AJ, Cupples LA, Anderson K, Kannel
WB. Relation of pooled logistic regression to time dependent Cox regression
analysis: the Framingham Heart Study. Statistics in Medicine, 1990; 9:1501-15.
Lee M-LT. A moment test to identify uniformity. Communications in Statistics: Simulation and Computation,
1989; 18 Part B:253-61.
Lee M-LT. Some cross product difference statistics and a test
for trends in ordered contingency tables. Statistics and Probability Letters, 1988; 7:41-46.
Block HW, Ting ML. Some concepts of multivariate dependence.
Communications in Statistics: Theory and Methods,
Limnios N, Lee M-LT. Hoeffding's Inequality for Stopped Martingales and Semi-Markov Processes. Communications in Statistics: Theory and Methods,
2005, 34: 713-720.
Lee M-LT, Whitmore GA. Stochastic processes directed by randomized
time. Journal of Applied Probability, 1993; 30:302-14.
Lee M-LT, Rachev ST, Samorodnitsky G. Association of stable random
variables. Annals of Probability, 1990; 18:1759-64.
Lee M-LT, Gross AJ. Properties of conditionally independent generalized
gamma distributions. Probability in the Engineering and Informational Sciences,
Lee M-LT. Dependence by reverse regular rule. Annals of Probability,
Lee M-LT. Dependence by total positivity. Annals of Probability,
Articles in Epidemiology,
Pharmarco Epidemiology, Microbiology & Environmental Studies
Rosner B, Glynn RJ, Lee M-LT. A Nonparametric Test for Observational Non-Normally Distributed Ophthalmic Data with Eye-Specific Exposures and Outcomes, Ophthalmic Epidemiology, Volume 14, Issue 4 July 2007, pages 243 - 250
Finkelstein JS, Lee M-LT, Sowers MF, Ettinger B, Neer RM, Kelsey
JL, Cauley JA, Huang MH, Greendale GA. Ethnic variation in bone density
in premenopausal and early perimenopausal women: effects of anthropometric
and lifestyle factors, Journal of Clinical Endocrinology and Metabolism,
2002; 87: 3057-3067.
Finkelstein JS, Sowers MF, Greendale GA, Lee M-LT, Neer RM, Cauley JA,
Ettinger B. Ethnic variation in bone turnover in pre- and early perimenopausal
women: effects of anthropometric and lifestyle factors. Journal of Clinical
Endocrinology and Metabolism, 2002; 87: 3051-3056.
Leder BZ, Smith MR, Fallon M, Lee ML, Finkelstein JS. Effects of gonadal
steroid suppression on skeletal sensitivity to parathyroid hormone
in men. Journal
of Clinical Endocrinology and metabolism, 2001; 86: 511-516.
Zaleznik DF, Rench MA, Hillier S, Krohn MA, Platt R, Lee M-LT, Flores
AE, Ferriri P, Baker CJ. Invasive group B streptococcal disease in
pregnant women and neonates from diverse population groups.
Infectious Diseases, 2000; 30:276-281.
Lee M-LT, Rosner BA, Weiss ST. Relationship of blood pressure
to cardiovascular death: the effects of pulse pressure in the elderly.
Annals of Epidemiology, 1999; 9: 101-107.
Platt R, Adelson-Mitty J, Weissman L, Zaleznik D., Lee ML, Baker CJ.
Resource utilization associated with initial hospital stays complicated
by early-onset group B streptococcal disease. Pediatric Infectious Disease,
1999; 18: 529-533.
Lee M-LT, Rosner BA, Weiss ST, Vokonas PS, Gaziano JM. Predictors
of cardiovascular deaths: The Normative Aging Study--1963-1998.
Clinical Geriatrics, 1999: 7: 77-85.
Fielding JR, Griffiths DJ, Versi E, Mulkern RV, Lee M-LT, Jolesz FA. MR
imaging of pelvic floor continence mechanisms in the supine and sitting positions.
American Journal of
Roentgenology, 1998; 171: 1607-1610.
Poteat HT, Ho GT, Lee M-LT, Welch WR, Loughlin KR, Sacks DB. The utility
of patient age in evaluating prostate cancer, American Journal of Clinical
Pathology, 1997; 107: 337-344.
Lee M-LT, Rosner BA, Vokonas PS, Weiss ST. Longitudinal analysis of adult
male blood pressure: The Normative Aging Study, 1963-1992. Journal of Epidemiology & Biostatistics, 1996;
Hirschorn LR, Trnka Y, Onderdonk A, Lee M-LT, Platt R. Epidemiology of
community-acquired clostridium difficile associated diarrhea. Journal
of Infectious Diseases, 1994; 169:127-33.
Choo PW, Rand CS, Inui TS, Lee M-LT, Canning C, Platt R. A cohort
study of possible risk factors for over-reporting of antihypertensive adherence,
BioMedical Central Cardiovascular Disorders, 2001;
Choo PW, Rand CS, Inui TS, Lee M-LT, Canning C, Platt R. Derivation
of adherence metrics from electronic dosing records. Journal of Clinical Epidemiology,
2001; 54: 619-626.
Choo PW, Rand CS, Inui TS, Lee M-LT, Canning C, Platt R. A pharmacodynamic
assessment of the impact of antihypertensive non-adherence on blood
pressure control. Pharmacoepidemiology and Drug Safety, 2000; 9:
Choo PW, Rand CS, Inui TS, Lee M-LT, Cain E, Cordeiro-Breault M, Canning
C, Platt R. Validation of patient reports, automated pharmacy records, and
pill counts with electronic monitoring or adherence to antihypertensive therapy.
Medical Care, 1999; 37: 846-857.
Lee M-LT, Lazarus R. Meta analysis for drug safety data with logistic
regressions. Drug Information Journal , 1997; 31: 1189-1193.
Onderdonk AB, Lee M-LT, Liberman E, Delaney ML, Tuomala RE. Quantitative
microbiologic models for pre-term delivery, Journal of Clinical Microbiology,
2003, 41: 1073-1079.
Lee M-LT, DuBois A, Ross RA, Onderdonk AB. Nonlinear models for in
vitro kill kinetics for antibiotics. Journal of Biopharmaceutical Statistics, 1999;
Lee M-LT, Ross RA, Onderdonk AB. Statistical models for vaginal
microflora: identifying women at risk for group B streptococcus
colonization as a test of concept. Infectious Diseases in Obstetrics and Gynecology.
1997; 5: 336-340.
Lee M-LT, Onderdonk AB. Demonstration of subgroups among normal vaginal
microflora data. Microbial Ecology in Health & Disease, 1995;
Lee M-LT, Ross RA, Onderdonk AB. Cluster analysis of vaginal microflora
data, Microecology and Therapy 1995; 25:324-328.
Lee M-LT, Ross RA, Delaney ML, Onderdonk AB. Mathematical modelling of
the vaginal microflora. Microecology and Therapy 1995; 23:18-21.
Ross RA, Lee M-LT, Delaney ML, Onderdonk AB. Use of continuous culture
growth systems for modelling vaginal microflora behaviour. Microecology
and Therapy 1995; 23:16-17.
Ross RA, Lee M-LT, Onderdonk AB. Effect of candida albricans infection
and clotrimazole treatment on vaginal microflora in an in vitro
and Gynecology, 1995; 86:925-30.
Lee M-LT, Ross RA, Delaney ML, Onderdonk AB. Predicting abnormal microbial
population levels in the vaginal ecosystem. Microbial Ecology in Health & Diseases,
Ross RA, Lee M-LT, Delaney ML, Onderdonk AB. Mixed-effects models for
predicting microbial interactions in the vaginal ecosystem. Journal of Clinical Microbiology,
Lee M-LT, Whitmore GA, Laden F, Hart JE, Garshick E. A Case-Control Study Relating Railroad Worker Mortality to Diesel Exhaust Exposure Using a Threshold Regression Model. Journal of Statistical Planning and Inferences, 2009, 139:1633-1642.
Lee M-LT, Whitmore GA, Laden F, Hart JE, Garshick E. Assessing lung cancer
risk in railroad workers using a first hitting time regression model. Environmetrics, 2004,15: 501-512.
Tsaih SW, Korrick S, Schwartz J, Lee MLT, Amarasiriwardena C, Aro A, Sparrow D, Hu H. Relation of bone lead and blood lead to renal function among middle-aged and elderly men: the Normative Aging Study. Environmental
Health Perspectives. 2004; 112: 1178-82.
Aro A, Amarasiriwardena C, Lee M-LT, Kim R, Hu H. Validation of K x-ray
fluorescence bone lead measurements by inductively coupled plasma
mass spectrometry in cadaver legs. Medical Physics,
2000; 27: 119-123.
Chuang HY, Schwartz J, Hu H, Lee M-LT. Vibration perception thresholds
in workers with long-term lead exposure. Occupational and Environmental
Medicine, 2000; 57: 588-594.
Tsaih SWT, Schwartz J, Lee M-LT, Amarasiriwardena C, Aro A, Sparrow D,
Hu H. The independent contribution of bone and erythrocyte lead
to urinary lead among middle-aged and elderly man: The Normative
Aging Study. Environmental
Health Perspectives, 1999; 107, 391-396.
Chuang HY, Lee M-LT, Chao KY, Wang JD, Hu H. The relationship of blood
lead levels to personal hygiene habits in lead battery workers: Taiwan,
1991-1997. American Journal of Industrial Medicine, 1999;