Mei-Ling Ting Lee


  1. LEE M-LT, Gail M, Pfeiffer R, Satten G, Cai T, Gandy A, editors, Risk Assessment and Evaluation of Predictions,(2013). Springer. ISBN 978-1-4614-8980-1

  2. LEE M-LT. Analysis of Microarray Gene Expression Data, (2004), Springer. ISBN 978-0-7923-7087-1

  3. Mesbah M, Cole BF, LEE M-LT, editors, Statistical Methods for Quality of Life Studies Design, Measurements and Analysis, (2002). Springer. ISBN 978-1-4020-0142-0

  4. Jewell NP, Kimber AC, LEE M-LT, Whitmore GA , editors, Lifetime Data: Models in Reliability and Survival Analysis, (1996). Springer. ISBN 978-0-7923-3783-6

Peer reviewed articles in the following areas

(Last updated on 5/28/2014)
  1. Analysis of Genomic Data
  2. Statistical Models and Applied Probability
  3. Applications in Epidemiology, Environmental Studies & Microbiology

Articles in Analysis of Genomic Data


Cruz-Cano R, Lee M-LT. Fast Canonical Correlation Analysis, Computational Statistics and Data Analysis, 2014, Vol. 70: 88-100, doi: 10.1016/j.csda.2013.09.020

Guth LM, Ludlow AT, Witkowski S, Marshall MR, Lima LCJ, Venezia AC, Xiao T, Lee M-LT, Spangenburg EE, Roth SM. Sex-specific Effects of Exercise Ancestry on Metabolic, Morphological, and Gene Expression Phenotypes in Multiple Generations of Mouse Offspring, Experimental Physiology, 2013, Vol. 98(10):1469-1484. doi: 10.1113/expphysiol.2012.070300

Cruz-Cano R, Lee M-LT, Leung MY. Logic Minimization and Rule Extraction for Identification of Functional Sites in Molecular Sequences, BioData Mining, 2012, Vol. 5:10. PMID: 22897894

Beyer SJ, Zhang X, Jimenez RE, Lee M-LT, Richardson AL, Huang, Jhiang SM. Microarray analysis of genes associated with cell surface NIS protein levels in breast cancer. BMC Research Notes, 2011, Vol. 4:397-410.  doi: 10.1186/1756-0500-4-397, PMID: 21989294

Lee M-LT. Molecular gene-signatures and cancer clinical trials, In: Designs for Clinical Trials: Perspectives on Current Issues. David Harrington, Editor, 2011, 139-155.

Hunter MP, Ismail N, Zhang X, Aguda BD, Lee EJ, Yu L, Xiao T, Schafer J, Lee M-LT, Schmittgen TD, Nana-Sinkam SP, Jarjoura D, Marsh C. Detection of microRNA Expression in Human Peripheral Blood Microvesicles, PLoS ONE, 2008, Vol. 3: 11, e3694. PMID: 19002258

Zhang Y, Bertolino A, Fazio L, Blasi G, Rampino A, Romano R, Lee M-LT, Xiao T, Papp A, Wang D, and Sadée W. Novel polymorphisms in the human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory, Proceedings of the National Academy of Sciences, USA, 2007, 104: 20552-20557. PMID: 18077373

Qiu W, Lee M-LT. SPCalc: A web-based calculator for sample size and power calculations in micro-array studies, Bioinformation, 2006, 1: 251-252. PMID: 17597901

Qin S, Qiu W, Ehrlich JR, Ferdinand AS, Richie JP, O扡eary MP, Lee M-LT, Liu BC-S. Development of a reverse capture autoantibody microarray for studies of antigen-autoantibody profiling. Proteomics, 2006, 6: 3199-3209. PMID: 16596707

Lee M-LT, Whitmore GA, Bjorkbacka H, Freeman M. Nonparametric Methods for Microarray Data Based on Exchangeability and Borrowed Power. Journal of Biopharmaceutical Statistics, 2005, 15: 783-797. PMID: 16078385

Tsai PW, LEE M-LT. Split-plot microarray experiments: issues of design, power and sample size. Applied Bioinformatics, 2005, 4: 187-194. PMID: 16231960

Lee M-LT, Gray RJ, Bjorkbacka H, Freeman MW. Generalized Rank Tests for Replicated Microarray Data. Statistical Applications in Genetics and Molecular Biology, 2005, Vol. 4: No. 1, Article 3. PMID: 16646848

Lee M-LT, Whitmore GA. Intensity-dependent normalization in microarray analysis: a note of concern. Bernoulli, 2004, 10: 943-949.

Lee M-LT, Whitmore GA, Yukhananov RY. Analysis of unbalanced microarray data, Journal of Data Science, 2003; 1: 103-121.

Lee M-LT, Whitmore GA. Power and sample size for microarray studies, Statistics in Medicine, 2002; 21: 3543-3570. PMID: 12436455

Lee M-LT, Bulyk ML, Whitmore GA, Church GM. A statistical model for investigating binding probability of DNA nucleotide sequences using microarrays, Biometrics, 2002; 58: 981-988. PMID: 12495153

Lee M-LT, Lu W, Whitmore GA, Beier D. Models for microarray gene expression data, Journal of Biopharmaceutical Statistics, 2002; 12: 1-19.

Lee M-LT, Kuo FC, Whitmore GA, Sklar J. Importance of replication in microarray gene expression studies: statistical methods and evidence from repetitive cDNA hybridization. Proceedings of the National Academy of Sciences, 2000; 97: 9834-9839. PMID: 10963655

Articles in Statistical Models and Applied Probability

Statistical Models

Shao F, Li J, Ma S, Lee, M-LT. Semiparametric Varying-coefficient Model for Interval Censored Data with a Cured Proportion, Statistics in Medicine, 2014, 33(10):1700-12. doi: 10.1002/sim.6054. PMID: 24302535

Whitmore GA, Zhang G, Lee M-LT. Constructing normalcy and discrepancy indexes for birth weight and gestational age using a threshold regression mixture model. Biometrics, 2012, 68: 297-306. PMID: 21838731

Xiao T, Whitmore GA, He X, Lee M-LT. Threg: a new command to implement threshold regression model in STATA. The STATA Journal, 2012, 12(2): 257-283.

Li L, Lee M-LT. Analysis of Failure Time Using Threshold Regression with Semi-parametric Varying Coefficients. Statistica Neerlandica, 2011, 65: 164-182.

Lee M-LT, Whitmore GA, Rosner B. Threshold Regression for Survival Data with Time-varying Covariates. Statistics in Medicine, 2010, 29, 7-8: 896 - 905. PMID: 20213704

Lee M-LT, Whitmore GA. Proportional hazards and threshold regression: their theoretical and practical connections. Lifetime Data Analysis, 2010, 16, 2: 196-214. PMID: 19960249

Pennell M, Whitmore GA, Lee M-LT. Bayesian random effects threshold regression with application to survival data with nonproportional hazards. Biostatistics, 2010, 11, 1: 111-126. PMID: 19828558

Yu Z, Tu W, Lee M-LT. A Semiparametric Threshold Regression Analysis of Sexually Transmitted Infections in Adolescent Women. Statistics in Medicine, 2009, 28:3029-3042. PMID: 19691037

Lee M-LT, Whitmore GA, Chang M. A Threshold Regression Mixture Model for Assessing Treatment Efficacy in a Multiple Myeloma Clinical Trial. Journal of Biopharmaceutical Statistics, 2008, 18: 1136-1149. PMID: 18991113

Tong X, He X, Sun J, and Lee M-LT. Joint analysis of current status and marker data: an extension of a bivariate threshold model. The International Journal of Biostatistics, 2008, Vol. 4: Iss. 1, Article 21. PMID: 20231913

Lee M-LT. Lifetime models and risk assessment. Encyclopedia of Quantitative Risk Assessments, Published Online in 2008. DOI: 10.1002/9780470061596.risk0478

Lee M-LT, Whitmore GA. Threshold regression for survival analysis: modeling event times by a stochastic process reaching a boundary. Statistical Sciences, 2006, 21: 501-513.

Rosner B, Glynn RJ, Lee M-LT. Extension of the Rank Sum Test for Clustered Data: Two-Group Comparisons with Group Membership Defined at the Subunit Level. Biometrics, 2006, 62: 1251-1259. PMID: 17156300

Rosner B, Glynn RJ, Lee M-LT. The Wilcoxon Signed Rank Test for Paired Comparisons of Clustered Data. Biometrics, 2006, 62: 185-192. PMID: 16542245

Lee M-LT, Dehling HG. Generalized two-sample U-statistics for clustered data. Statistica Neerlandica, 2005, 59: 313-323.

Shubina M., Lee M-LT. On maximum attainable correlation for Sarmanov family of bivariate distributions with equal marginal distributions, Communications in Statistics: Theory and Methods, 2004, 33: 1031-1052.

Rosner B, Glynn RJ, Lee M-LT, Incorporation of clustering effects for the Wilcoxon rank sum test: a large sample approach. Biometrics, 2003; 59: 1089-1098. PMID: 14969489

Lee M-LT, Whitmore GA. First Hitting Time Models for Lifetime Data, Handbook of Statistics, Volume 23: Advances in Survival Analysis, edited by N. Balakrishnan and C.R. Rao. Elsevier, North Holland. 2003; 537-543.

Fang HB, Sun J, Lee M-LT, Nonparametric survival comparisons for interval censored continuous data. Statistica Sinica, 2002; 12: 1073-1083.

Lee M-LT, Rosner BA. The average area under correlated ROC curves: a nonparametric approach based on generalized two-sample Wilcoxon statistics. Journal of Royal Statistical Society, series C, Applied Statistics, 2001; 50: 337-344.

Lee M-LT, Schoenfeld D, Wang X, Penfornis A, Faustman D. Bayesian analysis of case control polygenic etiology studies with missing data. Biostatistics; 2001, 2(3): 309-322. PMID: 12933541

Lee M-LT, DeGruttola V, Schoenfeld D. A model for markers and latent health status. Journal of Royal Statistical Society, Series B, 2000; 62: 747-762.

Lee M-LT, Whitmore GA. Statistical inference for serial dilution assay data. Biometrics, 1999; 55: 1215-1220. PMID: 11315070

Hougaard P, Lee M-LT, Whitmore GA. Analysis of overdispersed count data by mixtures of Poisson variables and Poisson processes. Biometrics, 1997; 53: 1225-1238. PMID: 9423246

Williamson JM, Lee M-LT. A GEE regression model for the association between an ordinal and a nominal variable. Communications in Statistics: Theory and Methods, 1996; 25:1887-1901.

Lee M-LT. Properties and applications of Sarmonov's family of bivariate distributions. Communications in Statistics: Theory and Methods, 1996; 25:1207-1222.

Cole BF, Lee M-LT, Whitmore GA, Zaslavsky AM. An empirical Bayes model for Markov dependent binary sequences with randomly missing observations. Journal of American Statistical Association, 1995; 90:1364-72.

Lee M-LT.  A two state Markov model.  Communications in Statistics: Theory and Methods, 1994; 23:615-23.

Benedetti J, Green S, Lee M-LT, Crowley J. Report of the ad hoc committee on design of experiments on double blind refereeing. Statistical Sciences, 1993; 8:318-30.

Lee M-LT, Gross AJ.  Lifetime distributions under unknown environments.  Journal of Statistical Planning and Inferences, 1991; 29:137-43.

Whitmore GA, Lee M-LT. A multivariate survival distribution generated by inverse Gaussian mixture of exponentials. Technometrics, 1991; 33:39-50.

D'Agostino RB, Lee M-LT, Belanger AJ, Cupples LA, Anderson K, Kannel WB.  Relation of pooled logistic regression to time dependent Cox regression analysis: the Framingham Heart Study.  Statistics in Medicine, 1990; 9:1501-15. PMID: 2281238

Lee M-LT.  A moment test to identify uniformity.  Communications in Statistics: Simulation and Computation, 1989; 18 Part B:253-61.

Lee M-LT.  Some cross product difference statistics and a test for trends in ordered contingency tables.  Statistics and Probability Letters, 1988; 7:41-46.

Block HW, Ting ML.  Some concepts of multivariate dependence.  Communications in Statistics: Theory and Methods, 1981; A10(8):749-62.

Applied Probability

Limnios N, Lee M-LT. Hoeffding's Inequality for Stopped Martingales and Semi-Markov Processes. Communications in Statistics: Theory and Methods, 2005, 34: 713-720.

Lee M-LT, Whitmore GA. Stochastic processes directed by randomized time. Journal of Applied Probability, 1993; 30:302-14.

Lee M-LT, Rachev ST, Samorodnitsky G. Association of stable random variables. Annals of Probability, 1990; 18:1759-64.

Lee M-LT, Gross AJ. Properties of conditionally independent generalized gamma distributions. Probability in the Engineering and Informational Sciences, 1989; 3:289-97.

Lee M-LT. Dependence by reverse regular rule. Annals of Probability, 1985; 13:583-91.

Lee M-LT. Dependence by total positivity. Annals of Probability, 1985; 13:572-82.

Wang HC, Ting ML.  Homogeneous Banach spaces of locally integrable functions.  Nanta Mathematica 1979; 12:62-70.

Articles in Epidemiology, Pharmarco Epidemiology, Microbiology & Environmental Studies


Hoh JK, Cha KJ, Park MI, Lee M-LT, Park YS. Estimating Time to Full Uterine Cervical Dilation Using Genetic Algorithm, Kaohsiung Journal of Medical Sciences, August 2012; 28(8): 423-428. PMID: 22892163

Rosner B, Glynn RJ, Lee M-LT. A Nonparametric Test for Observational Non-Normally Distributed Ophthalmic Data with Eye-Specific Exposures and Outcomes, Ophthalmic Epidemiology, July 2007; 14(4): 243-250. PMID: 17896304

Finkelstein JS, Lee M-LT, Sowers MF, Ettinger B, Neer RM,  Kelsey JL, Cauley JA, Huang MH, Greendale GA. Ethnic variation in bone density in premenopausal and early perimenopausal women: effects of anthropometric and lifestyle factors, Journal of Clinical Endocrinology and Metabolism, 2002; 87: 3057-3067. PMID: 12107201

Finkelstein JS, Sowers MF, Greendale GA, Lee M-LT, Neer RM, Cauley JA, Ettinger B. Ethnic variation in bone turnover in pre- and early perimenopausal women: effects of anthropometric and lifestyle factors. Journal of Clinical Endocrinology and Metabolism, 2002; 87: 3051-3056. PMID: 12107200

Leder BZ, Smith MR, Fallon M, Lee ML, Finkelstein JS. Effects of gonadal steroid suppression on skeletal sensitivity to parathyroid hormone in men. Journal of Clinical Endocrinology and metabolism, 2001; 86: 511-516. PMID: 11158001

Zaleznik DF, Rench MA, Hillier S, Krohn MA, Platt R, Lee M-LT, Flores AE, Ferriri P, Baker CJ. Invasive group B streptococcal disease in pregnant women and neonates from diverse population groups. Clinical Infectious Diseases, 2000; 30:276-281. PMID: 10671328

Lee M-LT, Rosner BA, Weiss ST. Relationship of blood pressure to cardiovascular death: the effects of pulse pressure in the elderly. Annals of Epidemiology, 1999; 9: 101-107. PMID: 10037553

Platt R, Adelson-Mitty J, Weissman L, Zaleznik D., Lee ML, Baker CJ. Resource utilization associated with initial hospital stays complicated by early-onset group B streptococcal disease. Pediatric Infectious Disease, 1999; 18: 529-533. PMID: 10391183

Lee M-LT, Rosner BA, Weiss ST, Vokonas PS, Gaziano JM. Predictors of cardiovascular deaths: The Normative Aging Study--1963-1998. Clinical Geriatrics, 1999: 7: 77-85.

Fielding JR, Griffiths DJ, Versi E, Mulkern RV, Lee M-LT, Jolesz FA. MR imaging of pelvic floor continence mechanisms in the supine and sitting positions. American Journal of Roentgenology, 1998; 171: 1607-1610. PMID: 9843296

Poteat HT, Ho GT, Lee M-LT, Welch WR, Loughlin KR, Sacks DB. The utility of patient age in evaluating prostate cancer, American Journal of Clinical Pathology, 1997; 107: 337-344. PMID: 9052385

Lee M-LT, Rosner BA, Vokonas PS, Weiss ST. Longitudinal analysis of adult male blood pressure: The Normative Aging Study, 1963-1992. Journal of Epidemiology & Biostatistics, 1996; 1:79-87. 

Hirschorn LR, Trnka Y, Onderdonk A, Lee M-LT, Platt R. Epidemiology of community-acquired clostridium difficile associated diarrhea. Journal of Infectious Diseases, 1994; 169:127-33. PMID: 8277174

Environmental Research

Pasturel BZ, Cruz-Cano R, Rosenberg Goldstein1, Palmer A, , Blythe D, Ryan P, Hogan B, Jung C, Joseph SW, Wang MQ, Lee M-LT, Puett R, Sapkota AR. Impact of rurality, broiler operations, and community socioeconomic factors on the risk of campylobacteriosis in Maryland, American Journal of Public Health, 2013, 103(12):2267-75. doi: 10.2105/AJPH.2013.301338, PMID: 24134343

Lee M-LT, Whitmore GA, Laden F, Hart JE, Garshick E. A Case-Control Study Relating Railroad Worker Mortality to Diesel Exhaust Exposure Using a Threshold Regression Model. Journal of Statistical Planning and Inferences, 2009, 139:1633-1642. PMID: 19221608

Lee M-LT, Whitmore GA, Laden F, Hart JE, Garshick E. Assessing lung cancer risk in railroad workers using a first hitting time regression model. Environmetrics, 2004,15: 501-512. PMID: 16741563

Tsaih SW, Korrick S, Schwartz J, Lee MLT, Amarasiriwardena C, Aro A, Sparrow D, Hu H. Relation of bone lead and blood lead to renal function among middle-aged and elderly men: the Normative Aging Study. Environmental Health Perspectives. 2004; 112: 1178-82.

Aro A, Amarasiriwardena C, Lee M-LT, Kim R, Hu H. Validation of K x-ray fluorescence bone lead measurements by inductively coupled plasma mass spectrometry in cadaver legs. Medical Physics, 2000; 27: 119-123. PMID: 10659745

Chuang HY, Schwartz J, Hu H, Lee M-LT. Vibration perception thresholds in workers with long-term lead exposure. Occupational and Environmental Medicine, 2000; 57: 588-594. PMID: 10935939

Tsaih SWT, Schwartz J, Lee M-LT, Amarasiriwardena C, Aro A, Sparrow D, Hu H. The independent contribution of bone and erythrocyte lead to urinary lead among middle-aged and elderly man: The Normative Aging Study. Environmental Health Perspectives, 1999; 107, 391-396. PMID: 10210695

Chuang HY, Lee M-LT, Chao KY, Wang JD, Hu H. The relationship of blood lead levels to personal hygiene habits in lead battery workers: Taiwan, 1991-1997. American Journal of Industrial Medicine, 1999; 35: 595-603. PMID: 10332513

Pharmarco Epidemiology

Choo PW, Rand CS, Inui TS, Lee M-LT, Canning C, Platt R. A cohort study of possible risk factors for over-reporting of antihypertensive adherence, BioMedical Central Cardiovascular Disorders, 2001; 1: 6. PMID: 11801191

Choo PW, Rand CS, Inui TS, Lee M-LT, Canning C, Platt R. Derivation of adherence metrics from electronic dosing records. Journal of Clinical Epidemiology, 2001; 54: 619-626. PMID: 11377123

Choo PW, Rand CS, Inui TS, Lee M-LT, Canning C, Platt R. A pharmacodynamic assessment of the impact of antihypertensive non-adherence on blood pressure control. Pharmacoepidemiology and Drug Safety, 2000; 9: 557-563. PMID: 11338913

Choo PW, Rand CS, Inui TS, Lee M-LT, Cain E, Cordeiro-Breault M, Canning C, Platt R. Validation of patient reports, automated pharmacy records, and pill counts with electronic monitoring or adherence to antihypertensive therapy. Medical Care, 1999; 37: 846-857. PMID: 10493464

Lee M-LT, Lazarus R. Meta analysis for drug safety data with logistic regressions. Drug Information Journal , 1997; 31: 1189-1193.


Onderdonk AB, Lee M-LT, Liberman E, Delaney ML, Tuomala RE. Quantitative microbiologic models for pre-term delivery, Journal of Clinical Microbiology, 2003, 41: 1073-1079. PMID: 12624032

Lee M-LT, DuBois A, Ross RA, Onderdonk AB. Nonlinear models for in vitro kill kinetics for antibiotics. Journal of Biopharmaceutical Statistics, 1999; 9: 271-277. PMID: 10379693

Lee M-LT, Ross RA, Onderdonk AB. Statistical models for vaginal microflora: identifying women at risk for group B streptococcus colonization as a test of concept. Infectious Diseases in Obstetrics and Gynecology. 1997; 5: 336-340. PMID: 18476181

Lee M-LT, Onderdonk AB. Demonstration of subgroups among normal vaginal microflora data. Microbial Ecology in Health & Disease, 1995; 7:107-12.

Lee M-LT, Ross RA, Onderdonk AB. Cluster analysis of vaginal microflora data, Microecology and Therapy 1995; 25:324-328.

Lee M-LT, Ross RA, Delaney ML, Onderdonk AB. Mathematical modelling of the vaginal microflora. Microecology and Therapy 1995; 23:18-21.

Ross RA, Lee M-LT, Delaney ML, Onderdonk AB. Use of continuous culture growth systems for modelling vaginal microflora behaviour. Microecology and Therapy 1995; 23:16-17.

Ross RA, Lee M-LT, Onderdonk AB. Effect of candida albricans infection and clotrimazole treatment on vaginal microflora in an in vitro model. Obstetrics and Gynecology, 1995; 86:925-30. PMID: 7501341

Lee M-LT, Ross RA, Delaney ML, Onderdonk AB. Predicting abnormal microbial population levels in the vaginal ecosystem. Microbial Ecology in Health & Diseases, 1994; 7:235-40.

Ross RA, Lee M-LT, Delaney ML, Onderdonk AB. Mixed-effects models for predicting microbial interactions in the vaginal ecosystem. Journal of Clinical Microbiology, 1994; 32:871-75. PMID: 8027337